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Furthermore, the incorporation of other biodegradable agents, such as hydrolyzable groups, drugs, or nanoparticles, can enhance the degradation rate and enable controlled release kinetics of therapeutic agents [191, 192]

Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects

Another important facet of the mtUPR is the upregulation of protein chaperones and antioxidant enzymes in response to elevated mitochondria oxidative stress

Eventually, the main determinant of brain delivery efficacy is the concentration of the active (parent) drug at site of action in the brain or an increase of the relative distribution of parent drug between the brain and other tissues after administration of prodrug or nanocarriers compared to parent drug dosing

Orlando (FL) Martin SL, Downey D, Bilton D, et al